synthesis of aspirin percent yield

The synthesis reaction of aspirin is shown below: Since acetic acid is very soluble in water, it is easily separated from the aspirin product. However, there will be some environmental effects that will still affect the experiment to a small extent. This preview shows page 1 - 2 out of 2 pages. Therefore, I had learnt that all wind source must be switched off and be kept away from when carrying out this process to ensure accuracy in results. However, there are side effects such as internal bleeding to the stomach and other internal organs and also cause people to experience asthma attacks and undesirable swellings (Vitamin Diary, Aspirin 2010). Synthesis of Aspirin By: Jon Torre Purpose: To determine which of four catalysts yields the fastest reaction rate in the acetylation of salicylic acid (1) to form acetylsalicylic acid (2). What are ten examples of solutions that you might find in your home? From simple essay plans, through to full dissertations, you can guarantee we have a service perfectly matched to your needs. We're here to answer any questions you have about our services. Describe in your own words what happens in each of the five main types of chemical reactions. Registered Data Controller No: Z1821391. Where are the reactants found? Informations sur votre appareil et sur votre connexion Internet, y compris votre adresse IP, Navigation et recherche lors de l’utilisation des sites Web et applications Verizon Media. It can also be used for a little complex treatment such as prevention of blood clots and prevent heart attack and stroke (Aspirin and Heart attacks 2005). Crystals together with the filter paper and the watch glass was then placed into desiccator for 5 to 10 minutes for all the liquid present to be drained. the reaction was not perfect (< 100% efficiency). Company Registration No: 4964706. Reference this. Reactions: Procedure and Results: Aspirin Synthesis Tap water was heated on a steam bath in a 250 mL beaker. Free resources to assist you with your university studies! You will determine the percent yield of aspirin and you will confirm it's identity with FT-IR spectroscopic anaylsis. When carrying out the suction filtration, it is strongly advisable to use 2 or more filter papers to prevent the tearing of the filter papers during the suction filtration due to the pressure. The aspirin formed will be contaminated with acetic acid and must be purified by recrystallization. Introducing Textbook Solutions. The major experimental findings are that, accuracy and attentiveness is very important in this experiment to obtain aspirin that is pure. Aspirin is also used to treat mild to moderate pain from conditions such as muscle aches, toothaches and headaches. and since acetic anhydride is in excess, salicylic acid will be the limiting agent. Calculate the percent yield of aspirin if you obtained 0.456 g of aspirin when you started with 0.6906 g of salicyclic acid. Our summaries and analyses are written by experts, and your questions are answered by real teachers. The melting temperature range of aspirin according to my experiment is between 134.2 ÌŠC to 136.1 ÌŠC. This was then put into the oven at 100oC for 15 – 20 minutes. Vous pouvez modifier vos choix à tout moment dans vos paramètres de vie privée. Study for free with our range of university lectures! This is not an example of the work produced by our Essay Writing Service. Nos partenaires et nous-mêmes stockerons et/ou utiliserons des informations concernant votre appareil, par l’intermédiaire de cookies et de technologies similaires, afin d’afficher des annonces et des contenus personnalisés, de mesurer les audiences et les contenus, d’obtenir des informations sur les audiences et à des fins de développement de produit. Aspirin has to be recrystallised several times to obtain purity. and in this case, 4.7 gm aspirin was generated, i.e. During the suction filtration of the solution, the recrystallised product is collected to the filter paper and was transferred to the watch glass. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group4. Salicylic acid was extracted from parts of willow trees (Dermaxime 2011). Using stoichiometry: 1 mole of salicylic acid generates 1 mole aspirin. After suction filtration is carried out the crude product is then collected. Organic Lab-Synthesis of Aspirin (percent yield)? Top subjects are Science, Math, and Business. This happened because all of what you collected as aspirin is not all aspirin. The aspirin crystals are packed into the small capillary tubes and make sure they are all compressed without air gaps. VAT Registration No: 842417633. Upon completion of the lab, analysis, and calculations, it is evident that t… Aspirin (C9H8O4) is generated from salicyclic acid (C7H6O3) and acetic anhydride (C4H6O3) using the following synthesis reaction: C7H6O3  + C4H6O3  -----> C9H8O4  +  C2H4O2. The aspirin was packed into the small capillary tubes and put into the optimelt melting apparatus to determine the melting temperature of Aspirin. This would lead to the crystals to be in contact with lots of water and cause the crystals to dissolve. Percent yield is the amount of substance we have obtained in total in the experiment. The main objective of the synthesis of aspirin lab was so produce aspirin (acetylsalicylic acid) through the reaction of salicylic acid and acetic anhydride. The weight of dried, recrystallised aspirin is then calculated. To calculate the expected mass of aspirin, we have to take the expected moles (f) which is 0.017391 mol multiply by the mr of aspirin 180. Hence, due to the pressure, the filter paper tore and our crude product entered the filter flask that was containing the impurities and other liquid. Aspirin works in our body by blocking certain natural substances in your body to reduce pain and swelling (Aspirin 2011). To obtain the percent yield of aspirin, we have to find the moles of salicylic acid used first by taking the mass of the salicylic acid which is 2.40g and divide by the mr of salicylic acid. To form aspirin, Salicylic acid is reacted with acetic anhydride using sulphuric acid as a catalyst to produce Aspirin and Acetic acid. This is accomplished by dissolving the acid in warm ethyl alcohol, adding cold water, and then allowing it to recrystallize in an ice bath. *You can also browse our support articles here >. Felic Hoffman who is a german chemistry formed aspirin in 1897 by looking into French Chemistry Charles Gergardt’s experiment and rediscovered the acetylsalicylic acid and produced stable state of aspirin (The Great Idea Finder 2006). Are you a teacher? This is so as these chemicals can cause irritation to body parts such as eyes and skin and can also cause bad burns. z2 C 7H 6O 3 + C 4H 6O 3 Æ2 C 9H 8O 4 + H2O salicylic acid acetic anhydride aspirin Percent Yields from Reactions. Then, a clean, dry watch glass with 2 filter papers was weighed and recorded. Introduction: The purpose of this experiment was to make aspirin via esterification, and to determine the percent yield we as a lab group made. Calculate the percent yield of aspirin if you obtained 0.456 g of aspirin when you started with 0.6906 g of salicyclic acid. Therefore the mass of dried, recrystallised aspirin is 1.45g. Percent yield = (mass of dried recrystallised aspirin / expected mass of aspirin) x 100%. The dried crystals together with the filter papers and watch glass was weighed and recorded. The theoretical melting temperature is 140 ÌŠC. In this experiment, the percent yield is 76.7% yield which shows that it is almost fully pure and contains lesser impurities. 1 mole of salicylic acid gives 1 mole of aspirin. Therefore, from this experiment I learn that I must be more alert and careful when I carry out suction filtration to avoid unnecessary hassle and inaccuracy of results and calculation. In this experiment, the crude product will be the desired product. It is the addition of water when carrying out suction filtration. If you need assistance with writing your essay, our professional essay writing service is here to help! The experimental yield percentage is different from the theoretical percentage is because there is loss of product often occurring during the isolation and purification steps (The Synthesis of Aspirin 2010). What could cause a percentage yield greater than 100? Since the range is near the theoretical value, this shows that the aspirin obtained is quite pure and hence contained fewer impurities. The percent yield was about 76.7% whereas the temperature range is between 134.2 to 136.1 ÌŠÌŠC. Figure 1: Esterification Reaction (Preparation of Aspirin 1996). 6. Firstly, approximately, 2.4g of salicylic acid was weighed into a dry 100ml conical flask and recorded. As we have to wash down the crystals before we carry out the suction filtration, some crystals might have dissolved. Hence, the amount of water we use to wash down the crystals during suction filtration might have affected the percent yield too. From both the calculations, I can evaluate that the aspirin is relatively pure to a however due to some experimental errors or improper techniques practiced, the percent yield is not up to expectation and moreover the incompletion of reaction might also be one of the reasons to the results obtained in this experiment. This would lead to loss of recrystallised crystals and cause variation in our calculations. Any opinions, findings, conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of The properties that allow this to take place is its bulky chemical group, solubility in water and its strong intermolecular forces between the aspirin molecules that allows it to make up the solid substance. The percent yield of the aspirin obtained from the experiment is 46.3% yield. For a limited time, find answers and explanations to over 1.2 million textbook exercises for FREE! The experimental yield percentage is different from the theoretical percentage is because there is loss of product often occurring during the isolation and purification steps (The Synthesis of Aspirin 2010).

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