Nearly 80% of American beer is treated with papain, which digests the precipitable protein fragments and causes the beer to remain clear upon cooling.Duke 1983 Commercially, papain is most commonly used in meat tenderizers and chewing gums.Duke 1983, Foster 1999 Cosmetically, papain is used in some dentifrices, shampoos, and facial creams.Duke 1983, Papaya has been widely used in folk medicine for many ailments: The juice has been used for warts, corns, cancers, tumors, and indurations of the skin; the roots or their extracts for uterine tumors, syphilis, yaws, or hemorrhoids, and to remove urine concretions; the unripe fruit for mild laxative or diuretic properties, and to stimulate lactation, labor, or abortion; the ripe fruit for rheumatism and alkalinizing the urine; the seeds for their anthelmintic properties or to stimulate menstruation or abortion; the leaves as a poultice for nervous pains and elephantoid growths, or smoked for asthma relief; and the latex for psoriasis, ringworm, or dyspepsia, or applied externally as an antiseptic or to heal burns or scalds, or smeared on the cervix as an ecbolic.Duke 1983, Gill 1992, Oderinde 2002. It is possible that papain, which is found in the papaya leaves and unripe fruit, may affect the international normalized ratio in patients maintained on warfarin.Shaw 1997. Reduced testosterone levels have been related to obesity, metabolic syndrome (MS), benign prostatic hypertrophy and even prostate cancer. About the Journal Int J Food Sci Nutr 2009;60 Suppl 6:32-46. All altered parameters, including percent fertility, were restored to control levels 120 days after treatment withdrawal.Manivannan 2009, In other studies, no signs of toxicity were observed in rats receiving a single oral dose of a methanolic extract of papaya seeds at 2,000 mg/kg,Lohiya 2006 or in those receiving 5,000 mg/kg of aqueous and methanolic extracts of whole, unripe C. papaya fruit.Ezike 2009, Another study in albino rats concluded that long-term daily oral administration of a methanolic extract of C. papaya seeds affects sperm parameters (count, viability, motility) and shows efficacy as a male contraceptive without causing adverse effects.Goyal 2010, Papain has demonstrated an ability to dissolve dead tissue without damaging living cells.Hewitt 2002, A study investigating the healing efficiency of papaya latex on burns induced in Swiss albino mice concluded that dried papaya latex 1% and 2.5% formulated in carbogel are both effective in the treatment of burns.Gurung 2009 There was an increase in the percentage of wound contraction observed from day 12 in the papaya 2.5%–treated group, and from day 20 in the papaya 1%–treated group and the standard treatment (silver sulfadiazine/chlorhexidine cream) group. All Special Issues Croatia: InTech; 2017. All participants were given 3 g of FPP daily during lunch for 2 months. Great, isn’t it? Zunjar V, Mammen D, Trivedi BM. One study used 20 mL of an elixir containing air-dried papaya seeds in honey (prepared by mixing 500 g of air-dried, machine-blended seeds with honey, for a total preparation volume of 1,000 mL [ie, 0.2 g of dried C. papaya seeds per milliliter]) to treat helminthiasis in children.Okeniyi 2007, In clinical studies, FPPs have been used at 6 to 9 g per day in divided doses to evaluate effects in patients with diabetes or hypothyroidism.Dickerson 2015, Somanah 2012, Tomella 2014, A commercial papaya preparation (Caricol; 20 mL) has been used for 40 days in a trial evaluating effects in GI disorders.Muss 2013.
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